These two clubs have met 12 times since 2009, with both enjoying six victories apiece. Arsenal won their first three home games, but Olympiacos have won each of their last three visits to North London, prevailing 3-2 in 2015, 2-1 after extra time in 2020 and 1-0 a year later.
Arsenal vs Olympiacos preview
Arsenal finished third in the inaugural league phase last season, very much targeting another top eight finish, so will they move three points closer to this target? On matchday one, the Gunners claimed an impressive 2-0 victory in Bilbao, beating Athletic Club 2-0 at San Mamés, thanks to late goals from substitutes Gabriel Martinelli and then Leandro Trossard, the pair setting up each-other.
Coming up in the league phase, Arsenal will welcome Atlético Madrid, Bayern Munich and Kairat to North London, with away trips to Slavia Prague, Club Brugge and Inter also on their schedule, so a top eight finish is more than ascertainable, considering around 16 points is the target.
Meantime, following three successive second-place finishes, all Gooners are desperate to see their side land that illusive Premier League title, so they were all celebrating in unison on Sunday. Mikel Arteta's team fought back from a goal down to beat Newcastle on Tyneside; Mikel Merino equalising five minutes from time, before a trademark Gabriel header deep into added time sparked wild celebrations in the away end and worldwide. This closes the gap to Liverpool to just two points but, before Saturday's clash with West Ham, will they collect three Champions League points here?
As for Olympiacos, this is their 21st appearance in the Champions League group stages since debuting in 1997, back for the first time in five seasons, having won the Europa Conference League in 2024, beating Fiorentina 1-0 in the final in Athens. Back at Europe's top table, the Red-Whites made an underwhelming start to the league phase, held to a goalless draw by debutants Pafos at Georgios Karaiskakis Stadium, despite the fact the visitors were reduced to ten men in the 24th minute.
This means, excluding qualifiers, Olympiacos have won only two of their last 21 Champions League matches, most-recently reaching the knockout stages in 2013/14. Considering they'll face Barcelona, Real Madrid, PSV, Leverkusen and Ajax, among others, after this, a top 24 finish may prove beyond José Luis Mendilibar's team. So, will Arsenal simply prove too strong on Wednesday night?
Arsenal vs Olympiacos head-to-head record
- Matches Played: 12.
- Arsenal Wins: 6. Draws: Zero. Olympiacos Wins: 6.
Arsenal team news
Mikel Arteta is without Piero Hincapié, Noni Madueke, Kai Havertz and Gabriel Jesus due to injury, but expect him to rotate, at least a bit, given both the Gunners' busy schedule and squad depth.
William Saliba, who signed a new five-year contract on Tuesday, is still nursing an ankle injury, so Cristhian Mosquera could start, as he did at St James' Park, before Saliba came on at half time.
Elsewhere, with Martin Ødegaard still suffering from a shoulder issue, Eberechi Eze was deployed centrally on Sunday, but could we see Ethan Nwaneri, considering the teenager has been the man to come on for Ødegaard during the home wins over both Leeds and Nottingham Forest?
Arsenal predicted lineup vs Olympiacos: (4-3-3): Raya, White, Mosquera, Gabriel, Lewis-Skelly; Zubimendi, Rice, Nwaneri; Saka, Eze, Gyökeres.
Arsenal player to watch vs Olympiacos
All three of Viktor Gyökeres' goals for Arsenal have come at home, while he bagged six in last season's league phase for Sporting, so can he add to his tally in North London?
Olympiacos team news
José Luis Mendilibar's side beat Levadiakos 3-2 on Saturday, likely to deploy a similar lineup here.
However, Lorenzo Scipioni and Roman Yaremchuk are both injured, while none of Rúben Vezo, Gustavo Mancha, Rémy Cabella nor Yusuf Yazıcı were included in the UEFA squad.
Daniel Podence will start; he scored for Wolves during a 2-1 away win over Arsenal in lockdown. Lastly, in goal, Konstantinos Tzolakis has started all five Greek Super League fixtures to date, but Alexandros Paschalakis got the nod against Pafos, so who will be chosen for this one?
Olympiacos predicted lineup vs Arsenal: (4-2-3-1): Paschalakis; Rodinei, Retsos, Pirola, Ortega; Hezze, García, Strefezza, Chiquinho, Podence; El Kaabi.
Olympiacos player to watch vs Arsenal
Ayoub El Kaabi has scored 63 goals in 101 appearances for Olympiacos, of which 23 have come in UEFA competition, bagging seven in last season's Europa League, as well as 11 in the Conference League the year before, historically bagging the extra time winner in the final against Fiorentina. So now, can the Moroccan international open his Champions League account?
Arsenal vs Olympiacos prediction
We're forecasting a low-key, comfortable Arsenal victory, with Mikel Arteta's team pretty hard to score against, while boasting plenty of attacking quality at the other end: Arsenal 2-0 Olympiacos.
Arsenal vs Olympiacos FAQs - UEFA Champions League
How to watch Arsenal vs Olympiacos in the Champions League on TV channel?
Arsenal vs Olympiacos in the Champions League will be available on the following TV channels;
- UK: TNT Sports 1 & Ultimate.
- USA: Paramount+
- Canada: DAZN Canada
How to watch Arsenal vs Olympiacos in the Champions League on live streaming?
Arsenal vs Olympiacos in the Champions League will be available on the following streaming services;
- UK: Discovery+
- USA: Paramount+
- Canada: DAZN Canada
What is the date and kick-off time for Arsenal vs Olympiacos in the Champions League?
Arsenal vs Olympiacos takes place on Wednesday 1 October 2025, with kick off at 20:00 (BST), 15:00 (EDT) & 12:00 (PDT).