These two clubs met for the very first time in the 2010 UEFA Super Cup, with Atlético Madrid 2-0 winners at Stade Louis II. Their sole subsequent encounter came in the Champions League round of 16 two seasons ago, with Atlético prevailing again, this time in a penalty shootout.
Inter are winless in 12 visits to Spain, dating back to a 5-1 win over Valencia back in 2004.
Atlético Madrid vs Inter Milan preview
These two clubs will both feel they are capable of making a deep run in this season's Champions League, so can either claim a statement win in the Spanish capital? Last season's beaten finalists Internazionale Milano have maximum points in the league phase so far, one of only three clubs to have achieved this, and the other two, Arsenal and Bayern, face each-other. Last time out, Carlos Augusto was the match-winner as Inter beat Kairat 2-1 at San Siro, following on from wins over Ajax, Slavia Prague and Royale Union Saint-Gilloise. Their remaining opponents though are Liverpool, Arsenal and then Borussia Dortmund, so it does only get tougher from here on out.
Meantime, in Serie A, Cristian Chivu's side suffered a serious set back on Sunday night, beaten 1-0 by fierce rivals AC Milan in the Derby della Madonnina. Christian Pulisic was the match-winner, while Hakan Çalhanoğlu saw a spot-kick saved 15 minutes from time. This is the Nerazzurri's fourth league defeat of the season already, also beaten by Udinese Juventus and Napoli, leading to many questioning how strong this side are in big games. So, can Inter get back on track with a win here?
As for Atlético Madrid, they are down in 17th in the gigantic Champions League table, having won both at home, but lost both on the road. Last month, los Colchoneros was hammered 4-0 by Arsenal in North London, all the goals coming during a 12 minute scoring spree, the joint-biggest defeat of Diego Simeone's 15-year tenure. At the Metropolitano meantime, Atleti have beaten Eintracht Frankfurt 5-1 and Union SG 3-1, Julián Álvarez, Conor Gallagher and Marcos Llorente netting in the latter, but they must improve if they're to gatecrash the top eight positions.
Meantime, in La Liga, after a disastrous start to the season, winning just one of their first five, Atlético Madrid have really found form, collecting 22 points out of the last 24 available. On Sunday, a late own goal saw Atleti beat city rivals Getafe 1-0 at the Coliseum, claiming a fifth league win in a row, now just four points adrift leaders Real Madrid, ahead of next Tuesday's crucial trip to Camp Nou. So, can los Colchoneros continue their excellent form when Inter visit on Wednesday?
Atlético Madrid vs Inter Milan head-to-head record
- Matches Played: 3.
- Atlético Madrid Wins: 2. Draws: Zero. Inter Milan Wins: 1.
Atlético Madrid team news
Juan Musso will deputise for the injured Jan Oblak in goal, while Diego Simeone is also without Robin Le Normand, meaning Clément Lenglet is likely to partner José María Giménez at centre-back, with Dávid Hancko chosen over Matteo Ruggeri on the left.
Elsewhere, Antoine Griezmann now has 203 goals for Atlético Madrid, including 39 in the Champions League, but he is no longer a guaranteed starter, with Alexander Sørloth set to come into the attack.
Atlético Madrid predicted lineup vs Inter Milan: (4-4-2): Musso; Molina, Giménez, Lenglet, Hancko; Koke, Barrios, Giuliano, Baena; Sørloth, Álvarez.
Atlético Madrid player to watch vs Inter Milan
The undisputed start of this team these days is Julián Álvarez, who has nine goals to his name this season, each of the last eight having been scored at the Metropolitano, so will he add to his tally?
Inter Milan team news
Following Sunday's derby defeat, it'll be interesting to see if Cristian Chivu changes much. Firstly, key man Denzel Dumfries is sidelined due to an ankle injury, so Carlos Augusto will deputise.
Meanwhile, fit again Marcus Thuram led the line in the Derby della Madonnina, starting for the first time since 27 September due to a hamstring injury, but will he be ready to go again so quickly?
Lastly, in midfield, in the continued absences of Henrikh Mkhitaryan, Petar Sučić will complete the trio alongside Hakan Çalhanoğlu and Nicolò Barella.
Inter Milan predicted lineup vs Atlético Madrid: (3-5-2): Sommer; Acerbi, Akanji, Bastoni; Carlos Augusto, Sučić, Çalhanoğlu, Barella, Dimarco; Bonny, Martínez.
Inter Milan player to watch vs Atlético Madrid
The last time Lautaro Martínez visited the Metropolitano, he missed the decisive penalty as Inter were dumped out of the Champions League. Now though, having scored eight goals so far this season, can he add to his 25 goals in the competition?
Atlético Madrid vs Inter Milan prediction
This Champions League clash could very much go either-way, so we're sitting on the fence and forecasting a low-scoring draw at the Metropolitano on Wednesday: Atlético Madrid 1-1 Inter Milan.
Atlético Madrid vs Inter Milan FAQs - UEFA Champions League
How to watch Atlético Madrid vs Inter Milan in the Champions League on TV channel?
Atlético Madrid vs Inter Milan in the Champions League will be available on the following TV channels;
- UK: TNT Sports 6
- USA: Paramount+
- Canada: DAZN Canada
How to watch Atlético Madrid vs Inter Milan in the Champions League on live streaming?
Atlético Madrid vs Inter Milan in the Champions League will be available on the following streaming services;
- UK: Discovery+
- USA: Paramount+
- Canada: DAZN Canada
What is the date and kick-off time for Atlético Madrid vs Inter Milan in the Champions League?
Atlético Madrid vs Inter Milan takes place on Wednesday 26 November 2025, with kick off at 20:00 (GMT), 15:00 (ET) & 12:00 (PT).