These two clubs have only ever met once before, with Monaco prevailing on away goals in the round of 16 after a thrilling 6-6 draw in Pep Guardiola's first season in Manchester.
Les Monégasques have won each of their last three home games against Premier League opposition, including beating Aston Villa 1-0 in January; Man City have won only two of their seven away games against Ligue 1 outfits.
Monaco vs Manchester City preview
Can Manchester City make it two wins out of two to start their Champions League campaign? On matchday one, the Sky Blues beat Napoli 2-0 at the Etihad, very much helped by the fact the reigning Scudetto winners were reduced to ten-men after 20 minutes. The Sky Blues eventually made their man advantage count, with Erling Braut Håland and then Jérémy Doku scoring quick-fire goals shortly after half time to secure victory. In last season's Champions League, Pep Guardiola's team finished 22nd, sneaking through to the knockout phase on the final matchday, only managing to beat Slovan Bratislava, Sparta Prague and Club Brugge, so they've already improved on that.
At the weekend, the Citizens swatted aside Burnley 5-1 at home, benefiting from two own goals, before Håland netted twice in injury time. This propelled Man City up to seventh, ahead of Sunday's visit to Brentford. In this competition meantime, after this trip to the Principality, they'll travel to Villarreal, Real Madrid and Bodø/Glimt while hosting Borussia Dortmund, Leverkusen and Galatasaray, so a top eight finish is more than ascertainable, looking to pick up three more points here.
As for Monaco, they won three of their four home games in the league phase last season, en route to a 17th place finish, before being dumped out by Benfica in the first knockout round. This time round, Adi Hütter's team made an inauspicious start, demolished 4-1 by Club Brugge. Maghnes Akliouche saw an early penalty saved, and this commenced a miserable night at Jan Breydelstadion, conceding four times in 43 minutes, with Ansu Fati's first goal since November 2023 late on scant consolation.
Meantime, in Ligue 1, after starting the season with four wins out of five, les Monégasques were beaten 3-1 by Lorient on Saturday, with Thilo Kehrer's red card on the cusp of half time Stade du Moustoir the major game-changing moment. So, in summary, Monaco are not among the European elite, meaning, if Manchester City play anywhere near their best, they'll leave Stade Louis II victorious.
Monaco vs Manchester City head-to-head record
- Matches Played: 2.
- Monaco Wins: 1. Draws: Zero. Manchester City Wins: 1.
Monaco team news
Adi Hütter is without Lukáš Hradecký, Denis Zakaria and Aleksandr Golovin due to injury, while Paul Pogba is still yet to make his debut, having not featured since 3 September 2023 due to a doping ban.
Monaco switched to a back three at the weekend, but fair to say that didn't work, so expect to see a four here, featuring Eric Dier, who donned the captain's armband in Brugge a fortnight ago.
In attack, Mika Biereth and George Ilenikhena led the line against Lorient, but USMNT striker Folarin Balogun could start this time, seeking a first-ever Champions League goal.
Monaco predicted lineup vs Manchester City: (4-4-2): Köhn; Vanderson, Dier, Kehrer, Caio Henrique; Camara, Bamba, Akliouche, Minamino; Balogun, Biereth.
Monaco player to watch vs Manchester City
Former Arsenal striker Mika Biereth scored 13 goals in 16 Ligue 1 appearances after joining Monaco in January last season, but has only netted once so far in this campaign. The Dane did bag two goals in the Champions League last season for Sturm Graz, so could he be the hero at Stade Louis II?
Manchester City team news
Pep Guardiola travels to the Principality without the injured Rayan Aït-Nouri, Abdukodir Khusanov, Rayan Cherki and Omar Marmoush, while Mateo Kovačić was an unused substitute against Burnley at the weekend, hoping to make his first appearance of the season following injury.
Rodri was not involved on Saturday, left out of the squad as a precaution, so will he return here, or will Nico González continue to deputise?
Manchester City predicted lineup vs Monaco: (4-3-3): Donnarumma; Nunes, Rúben Dias, Gvardiol, O'Reilly; Rodri, Reijnders, Foden, Silva, Doku; Håland.
Manchester City player to watch vs Monaco
Erling Braut Håland took his tally to 50 Champions League goals against Napoli, these coming against 17 different opponents, so can he add Monaco to that list?
Monaco vs Manchester City prediction
As already outlined, we cannot see beyond a Manchester City victory at Stade Louis II, likely to prove to be far too strong for a mid-tier Monaco team: Monaco 1-3 Manchester City.
Monaco vs Manchester City FAQs - UEFA Champions League
How to watch Monaco vs Manchester City in the Champions League on TV channel?
Monaco vs Manchester City in the Champions League will be available on the following TV channels;
- UK: TNT Sports 2
- USA: Paramount+, TUDN USA & Univision NOW
- Canada: DAZN Canada
How to watch Monaco vs Manchester City in the Champions League on live streaming?
Monaco vs Manchester City in the Champions League will be available on the following streaming services;
- UK: Discovery+
- USA: Paramount+, TUDN.com & UniMás
- Canada: DAZN Canada
What is the date and kick-off time for Monaco vs Manchester City in the Champions League?
Monaco vs Manchester City takes place on Wednesday 1 October 2025, with kick off at 20:00 (BST), 15:00 (EDT) & 12:00 (PDT).