Tottenham have never won either of their two previous visits to Stade Louis II, held to a 1-1 draw there in the Europa League in 2015, before a 2-1 Champions League defeat in the Principality a year later.
Monaco vs Tottenham preview
After a damaging defeat at the weekend, can Tottenham Hotspur get back on track in the French Riviera? On Sunday, despite leading inside four minutes through Rodrigo Bentancur, Spurs were beaten 2-1 by Aston Villa, the visitors' winner coming 13 minutes from time in North London. This means Thomas Frank's team have now failed to win any of their last three Premier League home games, thereby dropping down to sixth in the table.
Meantime, in the Champions League, the Lilywhites remain unbeaten, albeit only just. On matchday one, a fluke own goal saw them overcome Villarreal 1-0 at home. A fortnight later, Spurs found themselves 2-0 down against Bodø/Glimt, being completely outplayed in the Arctic Circle. Micky van de Ven halved the deficit at Aspmyra, before another own goal, this time in the final minute of the 90, ensured the points were shared in Northern Norway.

After this, Spurs' remaining league phase fixtures see them host København, Slavia Prague and Borussia Dortmund, as well as traveling to Paris Saint-Germain and Eintracht Frankfurt. With plenty of winnable games in there, Frank's team should certainly fancy their chances of a top eight finish. Here, will the reigning Europa League winners collect all three points in the Principality?
Monaco meantime managed to hold Manchester City to a 2-2 draw during their most-recent Champions League outing earlier this month. Jordan Teze struck a stunning equaliser, before Spurs cult hero Eric Dier converted an injury time penalty to pinch a point at Stade Louis II. This though has been a rare highlight for les Monégasques so far this season, demolished 4-1 by Club Brugge back on matchday one; Ansu Fati's late goal at Jan Breydelstadion very much of the consolation variety.

In Ligue 1, les Rouge et Blanc are currently seventh, without a win in three, following Saturday's 1-1 draw with Angers, in which Folarin Balogun broke the deadlock at Stade Raymond Kopa. This form saw manager Adi Hütter sacked during the international break, with Sébastien Pocognoli ditching Belgian champions Royale Union Saint-Gilloise to take over in the Principality. Fair to say, Stade Louis II never hosts the most raucous atmosphere one could find in European football, but Monaco certainly boast enough talent to spring a surprise when Spurs visit the French Riviera on Wednesday.
Monaco vs Tottenham Hotspur head-to-head record
- Matches Played: 4.
- Monaco Wins: 2. Draws: 1. Tottenham Hotspur Wins: 1.
Monaco team news
New manager Sébastien Pocognoli is without goalkeeper Lukáš Hrádecký as well as Christian Mawissa, Vanderson, Denis Zakaria, Lamine Camara, Paul Pogba and Eric Dier all due to injury.
Pogba still has not featured since 3 September 2023 due to a doping ban and now a lack of fitness, while Dier misses out on a meeting with his former side as a result of a muscle issue.

In terms of who will feature, Philipp Köhn will be donning the gloves, while Pocognoli deployed a back three for his first match in charge at Angers, thereby likely to stick with that system.
United States international striker Folarin Balogun scored off the bench at the weekend, so will he lead the attack, displacing fellow former-Arsenal academy graduate Mika Biereth in attack?
Monaco predicted lineup vs Tottenham Hotspur: (3-4-2-1): Köhn; Kehrer, Caio Henrique, Salisu; Diatta, Coulibaly, Bamba, Ouattara; Akliouche, Minamino, Balogun.
Monaco player to watch vs Tottenham
Maghnes Akliouche is Monaco's primary creative threat, on target during home wins over Le Havre and Strasbourg earlier this season, so can he help sink Spurs?
Tottenham team news
Cristian Romero was due to start against Aston Villa on Sunday, but pulled out after suffering an adductor problem during the warm-up, making him a doubt for this one, hence why Kevin Danso is likely to continue as Micky van de Ven's partner.

Elsewhere, Mathys Tel has led the line for the last two Premier League matches, but was controversially excluded from the UEFA squad, so Richarlison will start here. Deadline day signing Randal Kolo Muani still lacks match fitness according to Thomas Frank. Lastly, the aforementioned van de Ven will sit out next month's clash with København if cautioned.
Tottenham Hotspur predicted lineup vs Monaco: (4-3-3): Vicario; Porro, van de Ven, Danso, Spence; Palhinha, Bentancur, Simons; Kudus, Johnson, Richarlison.
Tottenham player to watch vs Monaco
Xavi Simons is still yet to score in Spurs colours but, now be deployed in his favoured number ten position, can he get off the mark?
Monaco vs Tottenham prediction
This clash at Stade Louis II is tough to call, but we are backing Tottenham for a narrow victory in the French Riviera, likely to just have too much quality for the hosts: Monaco 1-2 Tottenham Hotspur.
Monaco vs Tottenham FAQs - UEFA Champions League
How to watch Monaco vs Tottenham Hotspur in the Champions League on TV channel?
Monaco vs Tottenham Hotspur in the Champions League will be available on the following TV channels;
- UK: TNT Sports 3
- USA: Paramount+
- Canada: DAZN Canada
How to watch Monaco vs Tottenham Hotspur in the Champions League on live streaming?
Monaco vs Tottenham Hotspur in the Champions League will be available on the following streaming services;
- UK: Discovery+
- USA: Paramount+
- Canada: DAZN Canada
What is the date and kick-off time for Monaco vs Tottenham Hotspur in the Champions League?
Monaco vs Tottenham Hotspur takes place on Wednesday 22 October 2025, with kick off at 20:00 (BST), 15:00 (EDT) & 12:00 (PDT).