Each of the last three meetings between these two clubs have ended 1-1, while Napoli have won only one of their last 13 clashes with Internazionale.
Napoli vs Inter Milan preview
Back in May, Napoli pipped Internazionale Milano to the Scudetto on the final day of the season, the pair separated by just a solitary point, so who will lay down a serious marker on Saturday evening?
Seven matches into this Serie A season, the duo are locked on 15 points, but visitors Internazionale Milano may be feeling better about life right now. On Tuesday night, Cristian Chivu's side made it three wins out of three in the Champions League, demolishing Royale Union Saint-Gilloise 4-0 in Brussels; Denzel Dumfries, Lautaro Martínez, Hakan Çalhanoğlu and Francesco Pio Esposito all on target at Stade Constant Vanden Stock.
Meantime, back in Serie A, after suffering back-to-back defeats against Udinese and Juventus earlier in the campaign, the Nerazzurri have stabilised with four successive victories. Last Saturday night, Ange-Yoan Bonny broke the deadlock inside six minutes at Stadio Olimpico and, despite a Roma onslaught from there on out, Inter held on for a 1-0 victory in the capital. Venturing south once again this weekend, can Internazionale make themselves title favourites with a victory in Naples?
As for hosts Napoli, they were also on the road in Champions League action on Tuesday, but did not enjoy their European away day quite as much. Despite taking the lead through Scott McTominay, the Partenopei were demolished 6-2 by PSV Eindhoven at Philips Stadion, with striker Lorenzo Lucca sent off for dissent late on. Antonio Conte's team have now lost both Champions League away games, also defeated at Manchester City, crucially beating Sporting CP 2-1 in-between.
Domestically, well a similar story, with Napoli losing successive away matches, defeated by AC Milan at San Siro and when they visited Torino last weekend. The Partenopei do boast a perfect record at Stadio Diego Armando Maradona this season, overcoming Cagliari, Pisa and Genoa on home turf, but Conte's team are clearly not as cohesive as they were en route to Scudetto success last season. So, can Napoli claim a massive victory, or will Inter flex their muscles in this top of the table clash?
Napoli vs Inter Milan head-to-head record
- Matches Played: 178.
- Napoli Wins: 52. Draws: 45. Inter Milan Wins: 81.
Napoli team news
With Romelu Lukaku sidelined long-term and Rasmus Højlund, who had just started to find form, also injured, Lorenzo Lucca could continue to lead the attack, despite his needless red card in Eindhoven.
Much of the discussion right now surrounds whether Kevin De Bruyne and Scott McTominay can function in the same side, but both will once again start. Fellow Scotsman Billy Gilmour and André-Frank Zambo Anguissa will be doing much of the midfield legwork, with Stanislav Lobotka sidelined.
Napoli predicted lineup vs Inter Milan: (4-4-1-1): Milinković-Savić; Di Lorenzo, Beukema, Buongiorno, Spinazzola; Gilmour, Zambo Anguissa, McTominay, Politano; De Bruyne, Lucca.
Napoli player to watch vs Inter Milan
Scott McTominay's double against PSV took his tally to 16 goals for Napoli, one of which came against Inter at San Siro last season, so will he be the Neapolitan hero again?
Inter Milan team news
Cristian Chivu remains without striker Marcus Thuram, who suffered a thigh injury against Slavia Prague, but Inter now have quality back-ups, something they lacked last season, with both Ange-Yoan Bonny and Francesco Pio Esposito having scored during victories earlier this week.
Manuel Akanji could come into defence, after Stefan de Vrij was withdrawn at half time against Royale Union Saint-Gilloise, with Nicolò Barella and Henrikh Mkhitaryan both set to return to midfield. The pair were rested in Brussels, but will start alongside Hakan Çalhanoğlu, as was the case in Rome last weekend, meaning Piotr Zieliński and Davide Frattesi will be back on the bench, underlining the depth in this Inter squad right now.
Inter Milan predicted lineup vs Napoli: (3-5-2): Sommer; Bisseck, Akanji, Bastoni; Dumfries, Mkhitaryan, Çalhanoğlu, Barella, Dimarco; Bonny, Martínez.
Inter Milan player to watch vs Napoli
Lautaro Martínez remains Inter's talisman, bagging his sixth of the season in Belgium on Tuesday. He has scored five career goals against Napoli, but has failed to net during any of his last seven Serie A meetings with the Scudetto holders, so can he end that barren streak?
Napoli vs Inter Milan prediction
We are backing Inter for victory in Naples on Saturday evening. The Nerazzurri appear to be a bit stronger at the moment, although don't tune in expecting a goal-fest: Napoli 0-1 Inter Milan.
Napoli vs Inter Milan FAQs - Serie A
How to watch Napoli vs Inter Milan in Serie A on TV channel?
Napoli vs Inter Milan in Serie A will be available on the following TV channels;
- UK: TNT Sports 1 & DAZN UK.
- USA: FOX One, fuboTV & Paramount+
- Canada: Fubo Sports Network Canada
How to watch Napoli vs Inter Milan in Serie A on live streaming?
Napoli vs Inter Milan in Serie A will be available on the following streaming services;
- UK: Discovery+ & DAZN UK.
- USA: Foxsports.com, fuboTV & Paramount+
- Canada: fuboTV Canada
What is the date and kick-off time for Napoli vs Inter Milan in Serie A?
Napoli vs Inter Milan takes place on Saturday 25 October 2025, with kick off at 17:00 (BST), 12:00 (EDT) & 9:00 (PDT).