While Bundesliga clubs will only lose a total of 24 players, some big stars will be missing the action in January as the exciting Bundesliga title race enters the second half after the mid-season break.
Bayer Leverkusen, who currently top the league table, would've preferred there was no African Cup of Nations because they will lose several key players to the continental tournament.
After losing Victor Boniface to a groin injury (he'll be sidelined for six weeks), Bayer are set to lose centre-backs Edmund Tapsoba and Odilon Kossounou.
At the same time, their title competitors and record champions Bayern Munich are also set to miss key players at the back, with Kim Min-jae and Noussair Mazraoui's absences blowing a hole in their defensive reserves.
VfB Stuttgart, who are currently third in the league table, will have to do without star striker Serhou Guirassy, whose 17 strikes in 14 games places him second in the Bundesliga's top scorers list behind Bayern Munich's Harry Kane.
Here's a quick look at some of the clubs who will bid a temporary Auf Wiedersehen to their players:
Kim Min-Jae (South Korea), Noussair Mazraoui (Morocco)
Odilon Kossounou (Ivory Coast), Amine Adli (Morocco), Edmund Tapsoba (Burkina Faso)
Sebastien Haller (Ivory Coast), Ramy Bensebaini (Algeria)
Jeong Woo-Yeong (South Korea), Serhou Guirassy (Guinea), Silas Wamangituka (DR Congo), Hiroki Ito (Japan)
The next month will be a stern test for Xabi Alonso in his quest to win Leverkusen's first league title while also preparing his team for their Europa League knockout clashes.